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KMID : 0043320060290060497
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Archives of Pharmacal Research
2006 Volume.29 No. 6 p.497 ~ p.502
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Cytotoxic C-Benzylated Chalcone and Other Constituents of Ellipeiopsis cherrevensis
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Wirasathien Lalita
Pengsuparp Thitima
Moriyasu Masataka
Kawanishi Kazuko
Suttisri Rutt
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Abstract
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A new natural C-benzylated chalcone, 2’,4’-dihydroxy-3’-(2-hydroxybenzyl)-6￠-methoxychalcone (2), along with two other flavonoids, tiliroside and kaempferol 3-O-rutinoside, and an oxoaporphine alkaloid, lanuginosine were isolated from the aerial parts of Ellipeiopsis cherrevensis (Annonaceae). Two known polyoxygenated cyclohexene derivatives, ferrudiol and zeylenol, and a new analog, ellipeiopsol D, were also isolated. The chalcone 2 exhibited cytotoxic activity against human small-cell lung-cancer (NCI-H187), epidermoid carcinoma (KB) and breast cancer (BC) cell lines with IC50 values of 1.40, 5.31 and 13.92 μg/mL, respectively. This compound also showed antimalarial activity against Plasmodium falciparum with an IC50 value of 7.1 μg/mL as well as antimicrobacterial activity against Mycobacterium tuberculosis with a MIC of 25 mg/mL.
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KEYWORD
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Ellipeiopsis cherrevensis, Annonaceae, Flavonoids, Cyclohexene derivatives, Oxoaporphine alkaloid, Cytotoxicity
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